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Sunday 7 September 2008 |
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16:00 - 20:30 |
Registration |
| 17:30 - 19:00 |
“Advances in the Prevention of Invasive Meningococcal Disease” Sponsored by Novartis Vaccines and Diagnostics |
| Chairs: C. Frasch, Martinsburg, West Virginia, USA & R. Rappuoli, Siena, Italy | |
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R. Borrow, Manchester, United Kingdom M. Frosch, Würzburg, Germany M. Maiden, Oxford, United Kingdom D. Martin, Wellington, New Zealand M. Pizza, Siena, Italy |
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19:00- 20:30 |
Welcome Reception |
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Monday 8 September 2008 |
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08:30 - 10:30 |
Bacterial genetics, physiology and metabolism 1 |
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Chairs: C. Tang, London, United Kingdom & T. Tonjum, Oslo, Norway |
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| 08:30 - 08:50 | A cis-acting DNA element upstream of the pilin expression locus is required for pilin antigenic variation |
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H.S.S. Seifert, Chicago, USA |
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| 08:50 - 09:10 | DNA processing and secretion by the gonococcal type IV secretion system |
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J.P. Dillard, Madison, USA |
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| 09:10 - 09:30 | Broad spectrum o-linked protein glycosylation in Neisseria gonorrhoeae |
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Å.V. Vik, Oslo, Norway |
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| 09:30 - 09:50 | Identification of novel DNA binding proteins in Neisseria meningitidis |
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E. Lång, Oslo, Norway |
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| 08:50 - 10:10 | The structure of a DsbA-substrate complex: Implications for substrate recognition by oxidoreductases |
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C.M. Kahler, Nedlands, Perth, Australia |
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| 10:10 - 10:30 | Electron transfer to oxygen in Neisseria gonorrhoeae |
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J.A. Cole, Birmingham, United Kingdom |
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10:30 - 11:00 |
Coffee break |
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11:00 - 12:00 |
Bacterial genetics, physiology and metabolism 2 |
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Chairs: C. Tang, London, United Kingdom & T. Tonjum, Oslo, Norway |
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| 11:00 - 11:20 | A generic mechanism in Neisseria meningitidis for increased resistance against complement-mediated killing |
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E. Kugelberg, London, United Kingdom |
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| 11:20 - 11:40 |
Characterization of a zinc-regulated TonB-dependent receptor of Neisseria meningitidis |
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M. Stork, Utrecht, Netherlands |
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| 11:40 - 12:00 | Characterization of iron transport systems expressed by N. gonorrhoeae |
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C.N. Cornelissen, Richmond, USA |
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12:00 - 13:30 |
Lunch |
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13:30 - 15:30 |
Host and pathogen genomics and gene expression |
| Chairs: M. Frosch, Würzburg, Germany & C. Genco, Boston, USA | |
| 13:30 - 13:50 | Colonization of host cells by Neisseria meningitidis requires a cross talk between two two-component systems |
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P. Martin, Paris, France |
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| 13:50 - 14:10 | Structural studies of CrgA – Implications for transcriptional regulation in pathogenic Neisseria |
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S. Sainsbury, Oxford, United Kingdom |
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| 14:10 - 14:30 | Identification and functional characterization of sRNAs involved in the RpoE and Fur regulon of Neisseria meningitidis |
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Y. Pannekoek, Amsterdam, Netherlands |
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| 14:30 - 14:50 | Molecular and phenotypic characterization of the Hfq RNA chaperone of Neisseria meningitidis |
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I. Delany, Siena, Italy |
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| 14:50 - 15:10 |
The impact of the neisserial DNA uptake sequence on genome evolution and stability |
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O.H. Ambur, Oslo, Norway |
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| 15:10 - 15:30 |
Mechanisms Neisseria meningitidis utilize to evade the human antimicrobial peptide, LL-37 |
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A.L. Jones, Uppsala, Sweden |
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15:30 - 16:00 |
Tea break |
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16:00 - 17:00 |
Antibiotic resistance |
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Chairs: W. Shafer, Atlanta, USA & J. Vázquez, Madrid, Spain |
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| 16:00 - 16:20 |
Molecular characterization of the first ciprofloxacin-resistant strains of Neisseria meningitidis in the United States |
| B.H. Harcourt, Atlanta, USA | |
| 16:20 - 16:40 |
Structural and biochemical analysis of penA mutations conferring penicillin resistance in Neisseria gonorrhoeae |
| C. Davies, Charleston, USA | |
| 16:40 - 17:00 |
Development of an expanded WHO control panel of Neisseria gonorrhoeae for use in surveillance of gonococcal antimicrobial resistance |
| J.W. Tapsall, Sydney, Australia | |
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17:30 - 19:30 |
Parallel session 1: The Meningitis Vaccine Project |
| Chairs: Dr Hassan-King , MVP & Dr Konde, WHO | |
| 17:30 - 18:00 | Meningitis in the African Meningitis Belt |
| Dr Djingarey, WHO | |
| 18:00 - 18:30 | Safety and Immunogenicty of MenAfriVac |
| Dr Kulkarni, Serum Institute of India Limited & Dr Preziosi , MVP | |
| 18:30 - 19:00 | Expected Public Health Impact Following MenAfriVac Introduction |
| Dr LaForce | |
| 19:00 - 19:30 | Q&A and co-chairs conclusions |
| 17:30 - 20:30 | Parallel session 2: International Collaboration on Gonoccoci |
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The ICG group will present a series of short
presentations concentrating on optimising laboratory contributions to the
diagnosis of gonorhea. These will include diagnostics and genotyping, and
there will be special focus on global antimicrobial resistance surveillance
data, with an emphasis on the emerging problem of cephalosporin treatment
failure. Speakers include John Tapsall, Magnus Unemo, Cathy Ison, Jo-Anne Dillon, Eileen Yee, Robert Nicholas and David Lewis, among others. The meeting is open and any conference delegate is welcome to attend. Please visit the ICG website at www.ICGNGO.ORG for more information regarding ICG and previous meetings. |
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Tuesday 9 September 2008 |
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08:30 - 10:30 |
Host response, immunology and experimental therapy 1 |
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Chairs: D. Ala’Aldeen, Nottingham, United Kingdom & W. Zollinger, Washington, USA |
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| 08:30 - 08:50 | Naturally occurring lipid A mutants in Neisseria meningitidis associated with reduced coagulopathy in patients with meningococcal disease |
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F. Fransen, Bilthoven, Netherlands |
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| 08:50 - 09:10 | Studies of innate immune defences during Neisseria infection |
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A.-B. Jonsson, Uppsala, Sweden |
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| 09:10 - 09:30 |
Differential TLR2 binding of porins from pathogenic and non-pathogenic Neisseriae |
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P. Massari, Boston, USA |
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| 09:30 - 09:50 | A cyanobacterial LPS-antagonist inhibits cytokine production in human whole blood infected with Neisseria meningitidis |
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M. Christodoulides, Southhampton, United Kingdom |
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| 09:50 - 10:10 |
Differential induction of innate immunity to Neisseria lactamica and N. meningitidis in nasopharyngeal epithelial cells |
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L.B. Tezera, Bristol, United Kingdom |
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| 10:10 - 10:30 | The Th17 axis of immunity: a new dimension in comprehending the host response to Neisseria gonorrhoeae |
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M.W. Russell, Buffalo, USA |
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10:30 - 11:00 |
Coffee break |
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11:00 - 12:00 |
Host response, immunology and experimental therapy 2 |
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Chairs: D. Ala’Aldeen, Nottingham, United Kingdom & W. Zollinger, Washington, USA |
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11:00 - 11:20 |
Evasion of the adaptive immune system in the local mucosa during commensal colonisation of the upper respiratory tract by Neisseria lactamica but not Neisseria meningitidis |
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A.T. Vaughan, Bristol, United Kingdom |
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11:20 - 11:40 |
Experimental challenge of adult volunteers with Neisseria lactamica: Assessment of colonisation and immune responses |
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C. Evans, Sheffield, United Kingdom |
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11:40 - 12:00 |
Defining factors that govern alternative complement pathway activation on Neisseria meningitidis, with an emphasis on host specificity |
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S. Ram, Worcester, USA |
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12:00 - 13:30 |
Lunch |
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13:30 - 15:30 |
Host response, immunology and experimental therapy 3 |
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Chairs: M. van Deuren, Nijmegen, Netherlands & L. Wetzler, Boston, USA |
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13:30 - 13:50 |
Neisseria gonorrhoeae use factor H to adhere to complement receptor 3 on eukaryotic cells |
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S. Agarwal, Worcester, USA |
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13:50 - 14:10 |
Laminin receptor initiates contact of neurotropic bacteria with the blood brain barrier |
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D.A.A. Ala'Aldeen, Nottingham, United Kingdom |
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14:10 - 14:30 |
PorA strain variation causes differential processing, presentation and recognition of CD4 T cell epitopes |
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C.A.C.M. van Els, Bitlhoven, Netherlands |
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| 14:30 - 14:50 | Severely reduced B cell TACI expression in newborn mice plays role in impaired neonatal response against polysaccharide antigens |
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M. Akkoyunlu, Bethesda, USA |
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| 14:50 - 15:10 | B cells and the maintence of naturally acquired T cell memory to Neisseria meningitidis following colonization |
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S.J. Glennie, Bristol, United Kingdom |
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| 1510 - 15:30 | Tracking of human memory B cells specific for meningococcal serogroup C polysaccharide, induced by vaccination |
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M. Henneken, Reykjavik, Iceland |
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15:30 - 16:00 |
Tea break |
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16:00 - 17:00 |
Keynote lecture |
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Chair: P. van der Ley, Bilthoven, Netherlands |
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16:00 - 17:00 |
Meningococcal B vaccines from what we learned from the past and the present, especially from genomics of Neisseria, and a perspective for the future |
| R. Moxon, John Radcliffe Hospital, Oxford, United Kingdom | |
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19:30 - 22:30 |
Poster Session |
| 19:30 - 21:00 | Odd posternumbers |
| 21:00 - 22:30 | Even posternumbers |
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Wednesday 10 September 2008 |
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08:30 - 10:30 |
Session Vaccinology (preclinical) 1 |
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Chairs: I. Feavers, Potters Bar, United Kingdom & D. Granoff, Oakland, USA |
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| 08:30 - 08:50 | Multivalent group B meningococcal vaccine based on Native Outer Membrane Vesicles (NOMV) has potential for providing safe, broadly protective immunity |
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W.D. Zollinger, Silver Spring, USA |
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| 08:50 - 09:10 |
Broad meningococcal immunity elicited by bivalent native OMV vaccine from mutants engineered to have more than one factor H binding protein variant and detoxified endotoxin |
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O. Koeberling, Siena, Italy |
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| 09:10 - 09:30 | Genetically modified L3,7 and L2 lipooligosaccharides from Neisseria meningitidis serogroup B confer broad cross-bactericidal response: comparison with subunit protein approaches |
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J. Poolman, Rixensart, Belgium |
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| 09:30 - 09:50 | On Neisserial vaccine efforts: The art of war |
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R. Pajon Feyt, Calgary, Canada |
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| 09:50 - 10:10 | Review of proteomics as a tool in meningococcal vaccine development |
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C. Vipond, Potters bar, United Kingdom |
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| 10:10 - 10:30 | Neuraminic acid-containing polysialic acid is immunogenic and elicits antibodies that are protective against Neisseria meningitidis |
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G.R. Moe, Oakland, USA |
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10:30 - 11:00 |
Coffee break |
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11:00 - 12:00 |
Session Vaccinology (preclinical) 2 |
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Chairs: I. Feavers, Potters Bar, United Kingdom & D. Granoff, Oakland, USA |
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| 11:00 - 11:20 |
Prediction of broad vaccine coverage for a bivalent rLP2086 based vaccine which elicits serum bactericidal activity against a diverse collection of serogroup B meningococci |
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G.W. Zlotnick, Pearl River, USA |
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| 11:20 - 11:40 | Distribution and variability of 5CVMB vaccine antigen genes in a panel of strains representative of global meningococcal diversity |
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M.C. Comanducci, Siena, Italy |
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| 11:40 - 12:00 | Evaluation of recombinant Opa proteins as vaccine candidates against hyperinvasive meningococci |
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S. Lewis, Oxford, United Kingdom |
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12:00 - 17:30 |
Social Program / Time off |
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Thursday 11 September 2008 |
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08:30 – 10:30 |
Epidemiology 1 |
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Chairs: M. Maiden, Oxford, United Kingdom & A. van der Ende, Amsterdam, Netherlands |
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| 08:30 – 08:50 | Evolution of lineages and virulence in Neisseria meningitidis |
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K.A. Jolley, Oxford, United Kingdom |
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| 08:50 – 09:10 | Sequence diversity of vaccine candidate LP2086 in Neisseria meningitidis serogoup B strains causing invasive disease |
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S.K. Hoiseth, Pearl River, USA |
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| 09:10 – 09:30 |
The presence and genetic diversity of three meningococcal vaccine candidate genes, nadA, fHbp and gna2132, in ST-269 clonal complex isolates in England and Wales |
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J. Lucidarme, Manchester, United Kingdom |
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| 09:30 – 09:50 |
The haemoglobin receptor protein: a novel virulence determinant of Neisseria meningitidis |
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O.B. Harrison, Oxford, United Kingdom |
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| 09:50 – 10:10 | Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in Latin America region |
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J.A. Vázquez, Madrid, Spain |
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| 10:10 – 10:30 | Why Stop MeNZB vaccination? Supporting evidence for withdrawal of epidemic strain Outer Membrane Vesicle (OMV) vaccine in New Zealand (NZ) |
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D.R. Lennon, Auckland, New Zealand |
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10:30 – 11:00 |
Coffee break |
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11:00 – 12:00 |
Epidemiology 2 |
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Chairs: M. Maiden, Oxford, United Kingdom & A. van der Ende, Amsterdam, Netherlands |
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| 11:00 – 11:20 | Seroprevalence of antibodies against serogroup C meningococci in England in the post-vaccination era |
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C.L. Trotter, Bristol, United Kingdom |
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| 12:00 – 11:40 | Evidence of capsular switching in invasive Neisseria meningitidis isolates in the pre-meningococcal conjugate vaccine era, United States, 2000-2005 |
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L.H. Harrison, Pittsburgh, USA |
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| 11:40 – 12:00 | The effect of quadrivalent (A, C, Y, W-135) meningococcal conjugate vaccine on serogroup-specific carriage of Neisseria meningitidis |
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T.A. Clark, Atlanta, USA |
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12:00 – 13:30 |
Lunch |
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13:30 – 15:30 |
Cellular microbiology |
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Chairs: J. van Putten, Utrecht, Netherlands & M. Virji, Bristol, United Kingdom |
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| 13:30 – 13:50 | Caveolin recruitment prevents premature host cell entry of type IV pili producing Neisseria |
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J.P.B. Böttcher, Berlin, Germany |
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| 13:50 – 14:10 | A functional two-partner secretion system in Neisseria meningitidis contributes to adhesion |
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O. Kurzai, Würzburg, Germany |
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| 14:10 – 14:30 | Opc and its multifarious receptors – identification of novel mechanisms that may operate for attachment and traversal of human endothelial cells |
| M. Virji, Bristol, United Kingdom | |
| 14:30 – 14:50 | Infection of human cervical epithelial cells with live Neisseria gonorrhoeae promotes resistance to apoptosis |
| S.A. Follows, Boston, USA | |
| 14:50 – 15:10 |
Aspartyl protease complex presenilin/gamma-secretase liberates intracellular peptide signals into N. gonorrhoeae infected host cells by cleaving CD46 Cyt1 and Cyt2 isoforms |
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N.J.W. Weyand, Tucson, USA |
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| 15:10 – 15:30 | Host glycoprotein Gp96 and scavenger receptor SREC interact with PorB of disseminating Neisseria gonorrhoeae in an epithelial invasion pathway |
| C. Rechner, Berlin, Germany | |
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15:30 – 16:00 |
Tea break |
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16:00 – 17:00 |
Surface structures |
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M. Koomey, Oslo, Norway & J. Tommassen, Utrecht, Netherlands |
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| 16:00 – 16:20 | Outer membrane biogenesis in Neisseria meningitidis |
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M.P. Bos, Utrecht, Netherlands |
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| 16:20 – 16:40 | Transferrin binding protein B from different pathogenic species interact with transferrin in a conserved manner |
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A.B. Schryvers, Calgary, Canada |
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| 16:40 – 17:00 | Determination of the domain and solution structure of rLP2086, a meningococcal vaccine candidate and human factor H binding protein |
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G.W. Zlotnick, Pearl River, USA |
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18:00 – 23:00 |
Conference Diner |
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Friday 12 September 2008 |
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08: | |